Research consistently shows evidence-based social and behavior change (SBC) programs can increase knowledge, shift attitudes and norms and produce changes in a wide variety of behaviors. SBC has proven effective in several health areas, such as increasing the uptake of family planning methods, condom use for HIV prevention, and care-seeking for malaria. Between 2017 and 2019, a series of comprehensive literature reviews were conducted to consolidate evidence that shows the positive impact of SBC interventions on behavioral outcomes related to family planning, HIV, malaria, reproductive empowerment, and the reproductive health of urban youth in low- and middle-income countries. The result is five health area-specific databases that support evidence-based SBC. The databases are searchable by keyword, country, study design, intervention and behavior. The databases extract intervention details, research methodologies and results to facilitate searching. For each of the five health areas, a “Featured Evidence” section highlights a list of key articles demonstrating impact.